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The Bence-Jones protein urine test is used most often to diagnose and check on multiple myeloma, a type of cancer. Or an abnormal Bence-Jones test result may mean you have a type of malignant lymphoma. These are cancers of the lymphatic system. Multiple myeloma is a type of blood cancer that affects plasma cells. These are immune system cells that make antibodies to help fight infections. Most plasma cells live in bone marrow, so multiple myeloma tumors are often found in bone. Bone marrow is where blood cells are made. Multiple myeloma takes up space and leaves less space for normal bone marrow.